Inference on the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian Linear Mixed Models.

Détails

ID Serval
serval:BIB_CAAA8D7C418C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inference on the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian Linear Mixed Models.
Périodique
Genetics
Auteur(s)
Lloyd-Jones L.R., Robinson M.R., Moser G., Zeng J., Beleza S., Barsh G.S., Tang H., Visscher P.M.
ISSN
1943-2631 (Electronic)
ISSN-L
0016-6731
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
206
Numéro
2
Pages
1113-1126
Langue
anglais
Résumé
Genetic association studies in admixed populations are underrepresented in the genomics literature, with a key concern for researchers being the adequate control of spurious associations due to population structure. Linear mixed models (LMMs) are well suited for genome-wide association studies (GWAS) because they account for both population stratification and cryptic relatedness and achieve increased statistical power by jointly modeling all genotyped markers. Additionally, Bayesian LMMs allow for more flexible assumptions about the underlying distribution of genetic effects, and can concurrently estimate the proportion of phenotypic variance explained by genetic markers. Using three recently published Bayesian LMMs, Bayes R, BSLMM, and BOLT-LMM, we investigate an existing data set on eye (n = 625) and skin (n = 684) color from Cape Verde, an island nation off West Africa that is home to individuals with a broad range of phenotypic values for eye and skin color due to the mix of West African and European ancestry. We use simulations to demonstrate the utility of Bayesian LMMs for mapping loci and studying the genetic architecture of quantitative traits in admixed populations. The Bayesian LMMs provide evidence for two new pigmentation loci: one for eye color (AHRR) and one for skin color (DDB1).

Mots-clé
Africa, Western, Bayes Theorem, Color, Eye, Genetics, Population, Genome-Wide Association Study, Humans, Pigments, Biological/genetics, Polymorphism, Single Nucleotide/genetics, Quantitative Trait Loci, Skin Pigmentation/genetics, Bayesian linear mixed models, admixed populations, eye and skin color, genome-wide association studies
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2017 13:42
Dernière modification de la notice
09/05/2019 1:15
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