miRNA-mediated crosstalk between transcripts: The missing "linc"?

Détails

ID Serval
serval:BIB_CA9289D0481D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
miRNA-mediated crosstalk between transcripts: The missing "linc"?
Périodique
BioEssays : news and reviews in molecular, cellular and developmental biology
Auteur(s)
Tan J.Y., Marques A.C.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Statut éditorial
Publié
Date de publication
03/2016
Peer-reviewed
Oui
Volume
38
Numéro
3
Pages
295-301
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Recently, transcriptome-wide sequencing data have revealed the pervasiveness of intergenic long noncoding RNA (lncRNA) transcription. Subsets of lncRNAs have been demonstrated to crosstalk with and post-transcriptionally regulate mRNAs in a microRNA (miRNA)-dependent manner. Referred to as long noncoding competitive endogenous RNAs (lnceRNAs), these transcripts can contribute to diverse aspects of organismal and cellular biology, likely by providing a hitherto unrecognized layer of gene expression regulation. Here, we discuss the biological relevance of post-transcriptional regulation by lnceRNAs, provide insights on recent advances in the understanding of lnceRNA regulatory networks, and speculate on molecular factors that facilitate miRNA-dependent crosstalk between lnceRNAs and other transcripts.

Mots-clé
Animals, Humans, MicroRNAs/physiology, RNA Interference, RNA, Messenger/genetics, RNA, Messenger/metabolism, Transcription, Genetic
Pubmed
Création de la notice
16/02/2016 18:21
Dernière modification de la notice
03/03/2018 21:25
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