Erprobung neuer Gefassprothesen im arterio-venosen Shunt. [Evaluation of recent vascular prostheses in the arteriovenous shunt]

Détails

ID Serval
serval:BIB_CA8FB5E7ABDC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Erprobung neuer Gefassprothesen im arterio-venosen Shunt. [Evaluation of recent vascular prostheses in the arteriovenous shunt]
Périodique
Helvetica Chirurgica Acta
Auteur(s)
Walpoth  B. H., Ris  H. B., Amonn  A., Mettler  D., Schilt  W., Hoflin  F., Felix  R., Schaffner  T., Althaus  U.
ISSN
0018-0181 (Print)
Statut éditorial
Publié
Date de publication
10/1990
Volume
57
Numéro
2
Pages
347-50
Notes
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old url value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2074197 --- Old month value: Oct
Résumé
Prosthetic vascular replacement materials are still suboptimal especially for distal peripheral and coronary bypass grafts due to the small caliber and high occlusion rates. Therefore new vascular grafts have been assessed with respect to blood compatibility, thrombogenicity and host pretreatment. In 12 heparinized minipigs (25 kg), a total of 120 small caliber grafts (i.d. 3.0 mm) were perfused (6 min) in a femoro-femoral arteriovenous shunt (AVS). Materials included: Dacron (Atrium), PTFE (Gore), Polyurethanes (PU), Auto- and Xenografts. Animals were treated preoperatively with fishoil (3 g EPA/QD x 3 weeks = group I), perioperatively with prostaglandins (PGE1 = group II) or with fishoil and graft incubation in plasma proteins (= group III) and compared to controls without pretreatment (= group 0). We measured flow, deposition of marked thrombocytes (HMPAO-Tc* per area and per weight). - Blood flow was similar in AVS for all groups and materials (168 +/- 86 ml/min, p = NS). There was no significant correlation in deposition of marked thrombocytes and host pretreatments (group 0: controls = 7356 counts/area, group I: fishoil = 6807. group II: PGE1 = 7864). However graft incubation in plasma proteins significantly lowered deposition of marked thrombocytes (1766 in group III vs. 7356 in group 0: p less than 0.05). And significant differences of thrombocyte counts where found between the different materials: Autografts less than PTFE less than Xenografts less than Small Pore PU less than Dacron less than Large Pore PU.--AVS is a useful tool to determine early thrombogenicity in prosthetic vascular replacement materials and to assess the effect of different host pretreatments.
Mots-clé
Animals *Arteriovenous Shunt, Surgical Bioprosthesis *Blood Vessel Prosthesis Graft Occlusion, Vascular/*etiology Prosthesis Design Surface Properties Swine Swine, Miniature
Pubmed
Web of science
Création de la notice
29/01/2008 14:00
Dernière modification de la notice
03/03/2018 21:25
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