Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

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Version: Final published version
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Serval ID
serval:BIB_CA6AABC7CAE9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.
Journal
Journal of hepatology
Author(s)
Rubbia-Brandt L., Quadri R., Abid K., Giostra E., Malé P.J., Mentha G., Spahr L., Zarski J.P., Borisch B., Hadengue A., Negro F.
ISSN
0168-8278 (Print)
ISSN-L
0168-8278
Publication state
Published
Issued date
07/2000
Peer-reviewed
Oui
Volume
33
Number
1
Pages
106-115
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Patients infected with the hepatitis C virus (HCV) often have liver steatosis, suggesting the possibility of a viral cytopathic effect. The aim of this study was to correlate the occurrence and severity of liver steatosis with HCV RNA type, level and sequence of the core-encoding region.
We scored the liver steatosis in 101 HCV-infected individuals carefully selected to exclude other risk factors of a fatty liver. Results were compared with HCV RNA genotype and level in serum and liver. In selected patients, we assessed the effect of antiviral therapy on steatosis and the relationship between nucleocapsid sequence heterogeneity and fat infiltration.
Steatosis was found in 41 (40.6%) patients, irrespective of sex, age or route of infection. HCV genotype 3 was associated with higher steatosis scores than other genotypes. A significant correlation between steatosis score and titer of intrahepatic HCV RNA was found in patients infected with genotype 3, but not in those infected with genotype 1. In selected patients, response to alpha-interferon was associated with the disappearance of steatosis. Analysis of the nucleocapsid of 14 HCV isolates failed to identify a sequence specifically associated with the development of steatosis.
We provide virological and clinical evidence that the steatosis of the liver is the morphological expression of a viral cytopathic effect in patients infected with HCV genotype 3. At variance with published evidence from experimental models, the HCV nucleocapsid protein does not seem to fully explain the lipid accumulation in these patients.
Keywords
Adult, Aged, Amino Acid Sequence/genetics, Antiviral Agents/therapeutic use, Fatty Liver/virology, Female, Genotype, Hepacivirus/genetics, Hepatitis C, Chronic/complications, Hepatitis C, Chronic/immunology, Hepatitis C, Chronic/pathology, Hepatitis C, Chronic/virology, Humans, Immunocompetence, Interferon-alpha/therapeutic use, Liver Cirrhosis/drug therapy, Liver Cirrhosis/virology, Liver Transplantation, Male, Middle Aged, Molecular Sequence Data, Nucleocapsid Proteins/genetics, RNA, Viral/genetics
Pubmed
Web of science
Create date
11/06/2021 13:19
Last modification date
07/07/2021 6:12
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