Article: article from journal or magazin.
Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
An important question concerning the mechanism of somatic mutation of immunoglobulin variable (V) genes is whether it involves all of the numerous V genes in a differentiated B cell, independent of location, or if it is restricted to a particular chromosomal site. Comparison of the sequence of two alleles of a given V gene shows that the mutations are limited to the rearranged V gene, while the same V gene on the other chromosome has not undergone mutation. This indicates that a V gene sequence alone is not sufficient for somatic mutation to take place. The mutation is therefore restricted to the rearranged V gene and consequently does not occur before rearrangement.
Animals, Base Sequence, Binding Sites, Antibody/genetics, Chromosomes/physiology, DNA/genetics, Genes, Immunoglobulin Constant Regions/genetics, Immunoglobulin Variable Region/genetics, Immunoglobulins/genetics, Lymphocytes/metabolism, Mice, Mutation
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