Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_CA5F245B4828
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis.
Périodique
European Psychiatry : the Journal of the Association of European Psychiatrists
Auteur(s)
Schimmelmann B.G., Conus P., Cotton S., Kupferschmid S., McGorry P.D., Lambert M.
ISSN
1778-3585 (Electronic)
ISSN-L
0924-9338
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
27
Numéro
6
Pages
463-469
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
BACKGROUND: Previous studies on the impact of cannabis use disorders (CU) on outcome in psychosis were predominantly based on non representative samples, often have not controlled for confounders and rarely focused on adolescent patients. Thus, the aims of the present study were to assess: (i) prevalence of CU; (ii) baseline and pretreatment differences between CU and those without CU (NCU); (iii) the impact of baseline and course of CU on 18-month outcomes in a representative cohort of adolescents with early onset first episode psychosis (EOP).
METHODS: The sample comprised 99 adolescents (age 14 to 18) with EOP (onset age 14 to 17), admitted to the Early Psychosis Prevention and Intervention Centre in Australia. Data were collected from medical files using a standardized questionnaire.
RESULTS: Prevalence of lifetime CU was 65.7%, of current CU at baseline 53.5%, and of persistent CU throughout treatment 26.3%. Baseline CU compared to NCU had significantly higher illness-severity, lower psychosocial functioning, less insight, lower premorbid functioning and longer duration of untreated psychosis. Compared to all other groups, only persistent CU was linked to worse outcomes and more service disengagement. Effect sizes were medium controlling for relevant confounders. Medication non-adherence did not explain the association between persistent CU and worse outcome.
CONCLUSIONS: Baseline CU was associated with worse baseline characteristics, but only persistent CU was linked with worse outcome. About half of those with baseline CU reduced cannabis during treatment. For these, effectively treating the psychotic disorder may already be beneficial. However, future research is necessary on the reasons for persistent CU in EOP and its treatment.
Pubmed
Web of science
Création de la notice
18/08/2012 11:04
Dernière modification de la notice
20/08/2019 16:45
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