Article: article from journal or magazin.
Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.
Journal of Vascular Research
BACKGROUND/AIMS: The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS: Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior descending coronary artery. Eight animals underwent transthoracic echocardiography at rest and under low-dose dobutamine. Seven animals were examined by nuclear PET and SPECT analysis. Epi-, mid- and endocardial fibrosis and the numbers of arterial vessels were examined by histology. RESULTS: Functional analysis showed a significant decrease in global left ventricular ejection fraction (24.5 +/- 1.6%) 3 weeks after implantation. There was a trend to increased left ventricular ejection fraction after low-dose dobutamine stress (36.0 +/- 6.6%) and a significant improvement of the impaired regional anterior wall motion. PET and SPECT imaging documented chronic hibernation. Myocardial fibrosis increased significantly in the ischemic area with a gradient from epi- to endocardial. The number of arterial vessels in the ischemic area increased and coronary angiography showed abundant collateral vessels of Rentrop class 1. CONCLUSION: The presented experimental model mimics the clinical situation of chronic myocardial ischemia secondary to 1-vessel coronary disease.
Angioplasty, Transluminal, Percutaneous Coronary/adverse effects, Angioplasty, Transluminal, Percutaneous Coronary/instrumentation, Animals, Chronic Disease, Collateral Circulation, Coronary Angiography, Coronary Circulation, Coronary Stenosis/complications, Coronary Stenosis/diagnosis, Coronary Vessels/pathology, Coronary Vessels/physiopathology, Critical Illness, Disease Models, Animal, Echocardiography, Stress, Female, Fibrosis, Male, Myocardial Ischemia/diagnosis, Myocardial Ischemia/etiology, Positron-Emission Tomography, Severity of Illness Index, Stents/adverse effects, Stroke Volume, Swine, Time Factors, Tomography, Emission-Computed, Single-Photon, Ventricular Dysfunction, Left/etiology, Ventricular Dysfunction, Left/physiopathology
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