Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.

Détails

ID Serval
serval:BIB_CA52AB3910E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.
Périodique
Journal of Vascular Research
Auteur(s)
Horstick G., Bierbach B., Abegunewardene N., Both S., Kuhn S., Manefeld D., Reinecke H.J., Vosseler M., Helisch A., Becker D., Lauterbach M., Kempski O., Lehr H.A.
ISSN
1423-0135[electronic], 1018-1172[linking]
Statut éditorial
Publié
Date de publication
2009
Volume
46
Numéro
4
Pages
290-298
Langue
anglais
Résumé
BACKGROUND/AIMS: The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS: Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior descending coronary artery. Eight animals underwent transthoracic echocardiography at rest and under low-dose dobutamine. Seven animals were examined by nuclear PET and SPECT analysis. Epi-, mid- and endocardial fibrosis and the numbers of arterial vessels were examined by histology. RESULTS: Functional analysis showed a significant decrease in global left ventricular ejection fraction (24.5 +/- 1.6%) 3 weeks after implantation. There was a trend to increased left ventricular ejection fraction after low-dose dobutamine stress (36.0 +/- 6.6%) and a significant improvement of the impaired regional anterior wall motion. PET and SPECT imaging documented chronic hibernation. Myocardial fibrosis increased significantly in the ischemic area with a gradient from epi- to endocardial. The number of arterial vessels in the ischemic area increased and coronary angiography showed abundant collateral vessels of Rentrop class 1. CONCLUSION: The presented experimental model mimics the clinical situation of chronic myocardial ischemia secondary to 1-vessel coronary disease.
Mots-clé
Angioplasty, Transluminal, Percutaneous Coronary/adverse effects, Angioplasty, Transluminal, Percutaneous Coronary/instrumentation, Animals, Chronic Disease, Collateral Circulation, Coronary Angiography, Coronary Circulation, Coronary Stenosis/complications, Coronary Stenosis/diagnosis, Coronary Vessels/pathology, Coronary Vessels/physiopathology, Critical Illness, Disease Models, Animal, Echocardiography, Stress, Female, Fibrosis, Male, Myocardial Ischemia/diagnosis, Myocardial Ischemia/etiology, Positron-Emission Tomography, Severity of Illness Index, Stents/adverse effects, Stroke Volume, Swine, Time Factors, Tomography, Emission-Computed, Single-Photon, Ventricular Dysfunction, Left/etiology, Ventricular Dysfunction, Left/physiopathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/05/2009 20:30
Dernière modification de la notice
09/05/2019 1:14
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