Article: article from journal or magazin.
Circadian rhythm of plasma renin activity and plasma aldosterone in normal man and in renal allograft recipients
Proceedings of the European Dialysis and Transplant Association
In normal supine man, a marked circadian rhythm was found in plasma renin activity (PRA) and in plasma aldosterone concentration, with highest levels in the morning and lowest in the evening. Short-term suppression of ACTH by dexamethasone did not eliminate the circadian variation of plasma aldosterone. In patients with a transplanted and thus denervated kidney, no such rhythm of PRA could be observed. From our data it is suggested that the normal circadian rhythm of PRA depends on intact renal innervation and is controlled by the central nervous system.
Adrenocorticotropic Hormone/physiology Adult Aldosterone/*blood *Circadian Rhythm Dexamethasone/pharmacology Diet Female Humans Hydrocortisone/blood Kidney/innervation/physiology *Kidney Transplantation Male Middle Aged Nephrectomy Posture Prednisone/therapeutic use Renin/*blood Sodium Transplantation, Homologous
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