The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_CA23DA3DBC13
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.
Périodique
eLife
Auteur(s)
Ni L., Klein M., Svec K.V., Budelli G., Chang E.C., Ferrer A.J., Benton R., Samuel A.D., Garrity P.A.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Statut éditorial
Publié
Date de publication
29/04/2016
Peer-reviewed
Oui
Volume
5
Pages
e13254
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a set of exceptionally thermosensitive neurons critical for larval cool avoidance. Here, we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), a family of sensory receptors widely studied in invertebrate chemical sensing. We find that two IRs, IR21a and IR25a, are required to mediate DOCC responses to cooling and are required for cool avoidance behavior. Furthermore, we find that ectopic expression of IR21a can confer cool-responsiveness in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing. Together, these data show that IR family receptors can function together to mediate thermosensation of exquisite sensitivity.

Mots-clé
Animals, Behavior, Animal, Cold Temperature, Drosophila/physiology, Drosophila/radiation effects, Drosophila Proteins/metabolism, Receptors, Ionotropic Glutamate/metabolism, Thermosensing, D. melanogaster, animal behavior, neural circuits, neuroscience, thermoreceptor, thermosensation, thermosensor, thermotaxis
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/11/2015 22:54
Dernière modification de la notice
20/08/2019 15:45
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