Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.

Details

Serval ID
serval:BIB_C9E62C0D8CD1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.
Journal
Nature Genetics
Author(s)
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
2007
Volume
39
Number
12
Pages
1469-1476
Language
english
Abstract
The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.
Keywords
Animals, Bartonella/classification, Bartonella/genetics, Bartonella Infections, Evolution, Molecular, Genome, Bacterial, Genomics, Molecular Sequence Data, Phylogeny, Rats, Sequence Analysis, DNA, Virulence, Virulence Factors/genetics
Pubmed
Web of science
Create date
16/01/2014 16:48
Last modification date
20/08/2019 15:44
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