Lung Homeostasis: Influence of Age, Microbes, and the Immune System.

Details

Serval ID
serval:BIB_C99F6C9E5039
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lung Homeostasis: Influence of Age, Microbes, and the Immune System.
Journal
Immunity
Author(s)
Lloyd C.M., Marsland B.J.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
18/04/2017
Peer-reviewed
Oui
Volume
46
Number
4
Pages
549-561
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that continually monitor the external environment, and in health, instruct tolerance to innocuous inhaled particles while ensuring that efficient and rapid immune responses can be mounted against invading pathogens. Here we review the multiple pathways that underlie effective lung immunity in health, and discuss how these may be affected by external environmental factors and contribute to chronic inflammation during disease. In this context, we examine the current understanding of the impact of the microbiota in immune development and function and in the setting of the threshold for immune responses that maintains the balance between tolerance and chronic inflammation in the lung. We propose that host interactions with microbes are critical for establishing the immune landscape of the lungs.

Pubmed
Web of science
Create date
25/04/2017 18:20
Last modification date
20/08/2019 15:44
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