Inhibiteur acquis du facteur V traite par immunoglobulines intraveineuses. [Acquired factor V inhibitor treated with intravenous immunoglobulins]

Détails

ID Serval
serval:BIB_C988DDCEB333
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Inhibiteur acquis du facteur V traite par immunoglobulines intraveineuses. [Acquired factor V inhibitor treated with intravenous immunoglobulins]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Buclin  T., Schmidt  P. M., Hauert  J., Winkel  L., Chapuis  G., Bachmann  F.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1992
Volume
122
Numéro
51-52
Pages
1968-70
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Dec 26
Résumé
We report the appearance of a factor V inhibitor in an 82-year-old female patient following abdominal surgery. This anomaly was totally corrected following 9-day treatment with i.v. immunoglobulins (0.4 g/kg/day), which allowed a needed further surgical intervention to be performed without hemorrhagic diathesis. The activity of this inhibitor was partly reversed by the in vitro addition of immunoglobulins, suggesting a concentration-effect relationship. This finding supports the hypothesis that anti-idiotypic antibodies could play a role in the therapeutic effect of immunoglobulins in such situations.
Mots-clé
Aged Aged, 80 and over Antibodies, Anti-Idiotypic Blood Coagulation Disorders/immunology/*therapy Blood Coagulation Tests Factor V/*antagonists & inhibitors/immunology Female Humans Immunization, Passive/*methods Jejunostomy Postoperative Complications/therapy
Pubmed
Web of science
Création de la notice
21/01/2008 12:14
Dernière modification de la notice
03/03/2018 21:23
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