Normative volumes and relaxation times at 3T during brain development.
Details
Serval ID
serval:BIB_C96202C0E788
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normative volumes and relaxation times at 3T during brain development.
Journal
Scientific data
ISSN
2052-4463 (Electronic)
ISSN-L
2052-4463
Publication state
Published
Issued date
25/04/2024
Peer-reviewed
Oui
Volume
11
Number
1
Pages
429
Language
english
Notes
Publication types: Dataset ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
While research has unveiled and quantified brain markers of abnormal neurodevelopment, clinicians still work with qualitative metrics for MRI brain investigation. The purpose of the current article is to bridge the knowledge gap between case-control cohort studies and individual patient care. Here, we provide a unique dataset of seventy-three 3-to-17 years-old healthy subjects acquired with a 6-minute MRI protocol encompassing T1 and T2 relaxation quantitative sequence that can be readily implemented in the clinical setting; MP2RAGE for T1 mapping and the prototype sequence GRAPPATINI for T2 mapping. White matter and grey matter volumes were automatically quantified. We further provide normative developmental curves based on these two imaging sequences; T1, T2 and volume normative ranges with respect to age were computed, for each ROI of a pediatric brain atlas. This open-source dataset provides normative values allowing to position individual patients acquired with the same protocol on the brain maturation curve and as such provides potentially useful quantitative biomarkers facilitating precise and personalized care.
Keywords
Humans, Brain/diagnostic imaging, Brain/growth & development, Magnetic Resonance Imaging, Child, Child, Preschool, Adolescent, Male, Female, White Matter/diagnostic imaging, White Matter/growth & development, Gray Matter/diagnostic imaging
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2024 15:05
Last modification date
09/08/2024 15:06