Article: article from journal or magazin.
Behavioural and biochemical effects in C57BL/6J mice after a prolonged treatment with the delta-opiate antagonist ICI 154129
Journal of Pharmacy and Pharmacology
Journal Article --- Old month value: Dec
A long term treatment with the delta-selective opiate antagonist NN-bisallyl-Tyr-Gly-Gly-psi-(CH2S)-Phe-Leu-OH (ICI 154129) produces an increase in the number of delta-opiate binding sites, whereas the same treatment with the non selective opiate antagonist naloxone results in an enhancement of both mu- and delta-binding sites. This biochemical effect in naloxone-pretreated mice is paralleled by a more pronounced increase in locomotor activity induced by a challenge dose of morphine. In contrast, no difference in the effect of morphine was seen in ICI 154129-pretreated mice with respect to control. These data suggest that the locomotor response to morphine in C57 mice is not mediated through delta-opiate receptors.
Adrenergic alpha-Antagonists/*pharmacology Animals Behavior, Animal/*drug effects Brain Chemistry/*drug effects Brain Stem/metabolism Enkephalin, Leucine/*analogs & derivatives/pharmacology Enkephalin, Leucine-2-Alanine Levorphanol/pharmacology Male Mice Mice, Inbred C57BL Motor Activity/drug effects Naloxone/pharmacology Receptors, Opioid/*drug effects/metabolism Receptors, Opioid, delta
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