Scnn1 sodium channel gene family in genetically engineered mice.

Détails

ID Serval
serval:BIB_C9102261D234
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Scnn1 sodium channel gene family in genetically engineered mice.
Périodique
Journal of the American Society of Nephrology
Auteur(s)
Hummler E., Beermann F.
ISSN
1046-6673
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
11
Numéro
Suppl 16
Pages
S129-S134
Langue
anglais
Notes
Publication types: Journal Article
Résumé
The amiloride-sensitive epithelial sodium channel is the limiting step in salt absorption. In mice, this channel is composed of three subunits (alpha, beta, and gamma), which are encoded by different genes (Scnn1a, Scnn1b, and Scnn1c, respectively). The functions of these genes were recently investigated in transgenic (knockout) experiments, and the absence of any subunit led to perinatal lethality. More defined phenotypes have been obtained by introducing specific mutations or using transgenic rescue experiments. In this report, these approaches are summarized and a current gene-targeting strategy to obtain conditional inactivation of the channel is illustrated. This latter approach will be indispensable for the investigation of channel function in a wide variety of organ systems.
Mots-clé
Animals, Epithelial Sodium Channel, Gene Targeting, Genetic Engineering/methods, Mice, Mice, Knockout/genetics, Mice, Transgenic/genetics, Multigene Family, Mutation, Sodium Channels/deficiency, Sodium Channels/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 13:42
Dernière modification de la notice
20/08/2019 16:44
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