Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

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State: Public
Version: Final published version
Serval ID
serval:BIB_C905D0EAEA85
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Journal
Diabetes care
Author(s)
Nettleton J.A., McKeown N.M., Kanoni S., Lemaitre R.N., Hivert M.F., Ngwa J., van Rooij F.J., Sonestedt E., Wojczynski M.K., Ye Z., Tanaka T., Garcia M., Anderson J.S., Follis J.L., Djousse L., Mukamal K., Papoutsakis C., Mozaffarian D., Zillikens M.C., Bandinelli S., Bennett A.J., Borecki I.B., Feitosa M.F., Ferrucci L., Forouhi N.G., Groves C.J., Hallmans G., Harris T., Hofman A., Houston D.K., Hu F.B., Johansson I., Kritchevsky S.B., Langenberg C., Launer L., Liu Y., Loos R.J., Nalls M., Orho-Melander M., Renstrom F., Rice K., Riserus U., Rolandsson O., Rotter J.I., Saylor G., Sijbrands E.J., Sjogren P., Smith A., Steingrímsdóttir L., Uitterlinden A.G., Wareham N.J., Prokopenko I., Pankow J.S., van Duijn C.M., Florez J.C., Witteman J.C., Dupuis J., Dedoussis G.V., Ordovas J.M., Ingelsson E., Cupples L., Siscovick D.S., Franks P.W., Meigs J.B.
Working group(s)
MAGIC Investigators
Contributor(s)
Dupuis J., Claudia L., Prokopenko I., Saxena R., Soranzo N., Jackson A.U., Wheeler E., Glazer N.L., Bouatia-Naji N., Lindgren C.M., Mägi R., Morris A.P., Randal J., Rybin D., Johnson T., Henneman P., Gieger C., Thorleifsson G., Steinthorsdottir V., Dehghan A., Hottenga J.J., Franklin C.S., Navarro P., Song K., Goe A., Perry J.R., Lajunen T., Grallert H., Li M., Stringham H.M., Kumari M., Timpson N.J., Shrader P., Ingelsson E., Zabena C., O'Connell J., Cavalcanti-Proença C., Luan J., Elliott A., McCarroll S.A., Payne F., Roccasecca R.M., Sethupathy P., Andrew T., Ariyurek Y., Balkau B., Barter P., Bennett A.J., Ben-Shlomo Y., Bergmann S., Bochud M., Boerwinkle E., Bonnefond A., Bonnycastle L.L., Böttcher Y., Brunner E., Bumpstead S.J., Chen Y.D., Chines P., Clarke R., Coin L.J., Crawford G.J., Crisponi L., Day I.N., Geus Ed, Dina C., Doney A., Egan J.M., Elliott P., Erdos M.R., Fischer-Rosinsky A., Forouhi N.G., Fox C.S., Frants R., Franzosi M.G., Galan P., Goodarzi M.O., Graessler J., Groves C.J., Grundy S., Gwilliam R., Hallmans G., Hammond N., Han X., Hartikainen A.L., Hayward C., Heath S.C., Hercberg S., Herder C., Hicks A.A., Hingorani A.D., Hofman A., Isomaa B., Jula A., Kaakinen M., Kanoni S., Kesaniemi Y.A., Kivimaki M., Knight B., Koskinen S., Kovacs P., Lathrop G.M., Lawlor D.A., Li Y., Lyssenko V., Mahley R., Mangino M., Manning A.K., Martínez-Larrad M.T., McAteer J.B., McPherson R., Meisinger C., Melzer D., Meyre D., Mitchell B.D., Morken M.A., Naitza S., Narisu N., Neville M.J., Oostra B.A., Orrù M., Pakyz R., Palmer C.N., Paolisso G., Pattaro C., Pearson D., Peden J.F., Perola M., Pfeiffer A.F., Pichler I., Polasek O., Posthuma D., Potter S.C., Pouta A., Psaty B.M., Rathmann W., Rayner N.W., Rice K., Ripatti S., Rivadeneira F., Rolandsson O., Sandhu M., Sanna S., Sayer A.A., Scheet P., Scott L.J., Seedorf U., Sharp S.J., Shields B., Sijbrands E.J., Silveira A., Singleton A., Smith N.L., Sovio U., Swift A., Syddall H., Syvänen A.C., Tanaka T., Tönjes A., Tuomi T., Uitterlinden A.G., van Dijk K.W., Varma D., Visvikis-Siest S., Vitart V., Vogelzangs N., Waeber G., Wagner P.J., Watkins H., Weedon M.N., Wild S.H., Willemsen G., Witteman J.C., Yarnell J.W., Zelenika D., Zethelius B., Zhai G., Zhao J.H., Zillikens M.C., GIANT Consortium X., Global BPgen Consortium X., Loos R.J., Meneton P., Nathan D.M., Williams G.H., Hattersley A.T., Silander K., Salomaa V., Smith G.D., Bornstein S.R., Schwarz P., Spranger J., Karpe F., Shuldiner A.R., Cooper C., Dedoussis G.V., Serrano-Ríos M., Morris A.D., Lind L., Franks P.W., Ebrahim S., Marmot M., Kuusisto J., Laakso M., Kao W.H., Pankow J.S., Pramstaller P.P., Wichmann H.E., Illig T., Rudan I., Wright A., Stumvoll M., Campbell H., Wilson J.F., Hamsten A., Bergman R.N., Buchanan T.A., Collins F.S., Mohlke K.L., Tuomilehto J., Valle T.T., Altshuler D., Rotter J.I., Siscovick D.S., Penninx B.W., Boomsma D., Deloukas P., Spector T.D., Frayling T.M., Ferrucci L., Kong A., Thorsteinsdottir U., Stefansson K., van Duijn C.M., Aulchenko Y.S., Cao A., Scuteri A., Schlessinger D., Uda M., Ruokonen A., Jarvelin M.R., Waterworth D.M., Vollenweider P., Peltonen L., Mooser V., Abecasis G.R., Wareham N.J., Sladek R., Froguel P., Watanabe R.M., Meigs J.B., Groop L., Boehnke M., McCarthy M.I., Florez J.C., Barroso I.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Publication state
Published
Issued date
12/2010
Peer-reviewed
Oui
Volume
33
Number
12
Pages
2684-2691
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis Publication Status: ppublish

Abstract
Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.
Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant.
Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.
Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.

Keywords
Adult, Aged, Blood Glucose/genetics, Blood Glucose/metabolism, Edible Grain, European Continental Ancestry Group, Fasting/blood, Female, Genetic Loci/genetics, Genome-Wide Association Study, Genotype, Humans, Insulin/blood, Insulin/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics
URN
urn:nbn:ch:serval-BIB_C905D0EAEA857
OAI-PMH
oai:serval.unil.ch:BIB_C905D0EAEA85
DOI
10.2337/dc10-1150
Pubmed
20693352
Create date
02/10/2014 11:54
Last modification date
20/08/2019 15:44
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