Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison of non-osteoarthritic (OA) and severe OA knees.

Détails

ID Serval
serval:BIB_C8EEA5AC4A42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison of non-osteoarthritic (OA) and severe OA knees.
Périodique
Osteoarthritis and cartilage
Auteur(s)
Omoumi P., Babel H., Jolles B.M., Favre J.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Statut éditorial
Publié
Date de publication
11/2017
Peer-reviewed
Oui
Volume
25
Numéro
11
Pages
1850-1857
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
This study aimed to compare subchondral bone mineral density (sBMD) between non-radiographic osteoarthritic (OA) and medial femorotibial OA knees, using computed tomography (CT).
CT exams from 16 non-radiographic OA (KL grade < 2) and 16 severe medial OA (KL grade ≥ 3) knees (average age of 61.7 ± 3 and 62.2 ± 5 years old respectively, 50% male in each group), were retrospectively analyzed. CT exams were segmented and 3D maps of sBMD based on the CT number in the most superficial 3 mm of femoral and tibial subchondral bone were computed. Average sBMD and medial-to-lateral sBMD ratios were calculated for total load-bearing regions and for sub-regions of interest in the femur and tibia.
The analysis of total load-bearing regions did not reveal any significant difference between groups, except for the lateral tibia, where OA knees had lower sBMD. Sub-regional analysis unveiled differences with some sub-regions of the femur and tibia presenting significantly lower (in the lateral compartment) or higher (in the medial compartment) sBMD in OA knees compared to non-OA knees. The M/L sBMD ratios were significantly higher for OA knees compared to non-OA knees for all regions and sub-regions, except for the internal sub-regions.
sBMD locally differs between non-OA and OA knees, in agreement with prior knowledge on biomechanics. CT proved to be a valuable tool for 3D analysis of femoral and tibial sBMD, which can be used in future studies to describe the chronology of sBMD alterations and improve our understanding of the role of subchondral bone in knee OA.
Mots-clé
Aged, Arthrography, Bone Density, Case-Control Studies, Female, Femur/diagnostic imaging, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Knee Joint/diagnostic imaging, Male, Middle Aged, Osteoarthritis, Knee/diagnostic imaging, Radiography, Retrospective Studies, Tibia/diagnostic imaging, Tomography, X-Ray Computed, Weight-Bearing, Bone mineral density, Computed tomography (CT), Osteoarthritis (OA), Quantitative, Subchondral bone
Pubmed
Web of science
Création de la notice
07/08/2017 13:22
Dernière modification de la notice
20/08/2019 15:44
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