Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes

Détails

ID Serval
serval:BIB_C8C762C6EA2A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes
Périodique
Human Molecular Genetics
Auteur(s)
Fougerousse  F., Bullen  P., Herasse  M., Lindsay  S., Richard  I., Wilson  D., Suel  L., Durand  M., Robson  S., Abitbol  M., Beckmann  J. S., Strachan  T.
ISSN
0964-6906 (Print)
Statut éditorial
Publié
Date de publication
01/2000
Volume
9
Numéro
2
Pages
165-73
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 22
Résumé
Our understanding of early human development has been impeded by the general difficulty in obtaining suitable samples for study. As a result, and because of the extraordinarily high degree of evolutionary conservation of many developmentally important genes and developmental pathways, great reliance has been placed on extrapolation from animal models of development, principally the mouse. However, the strong evolutionary conservation of coding sequence for developmentally important genes does not necessarily mean that their expression patterns are as highly conserved. The very recent availability of human embryonic samples for gene expression studies has now permitted for the first time an assessment of the degree to which we can confidently extrapolate from studies of rodent gene expression patterns. We have found significant human-mouse differences in embryonic expression patterns for a variety of genes. We present detailed data for two illustrative examples. Wnt7a, a very highly conserved gene known to be important in early development, shows significant differences in spatial and temporal expression patterns in the developing brain (midbrain, telencephalon) of man and mice. CAPN3, the locus for LGMD2A limb girdle muscular dystrophy, and its mouse orthologue differ extensively in expression in embryonic heart, lens and smooth muscle. Our study also shows how molecular analyses, while providing explanations for the observed differences, can be important in providing insights into mammalian evolution.
Mots-clé
5' Untranslated Regions/genetics Amino Acid Sequence Animals Base Sequence Brain/embryology Calpain/biosynthesis/genetics Embryonic and Fetal Development/genetics Exons/genetics *Gene Expression Regulation, Developmental *Genes Genetic Diseases, Inborn/*genetics Humans *Isoenzymes Mice Molecular Sequence Data *Muscle Proteins Peptide Fragments/biosynthesis/genetics Promoter Regions (Genetics)/genetics Protein Biosynthesis Proteins/genetics *Proto-Oncogene Proteins Species Specificity Wnt Proteins
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:17
Dernière modification de la notice
09/05/2019 1:10
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