Mécanismes d'action de la gonadolibérine au niveau des cellules gonadotropes hypophysaires [Mechanism of action of gonadoliberin in pituitary gonadotropic cells]

Détails

ID Serval
serval:BIB_C8B8327DD86B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mécanismes d'action de la gonadolibérine au niveau des cellules gonadotropes hypophysaires [Mechanism of action of gonadoliberin in pituitary gonadotropic cells]
Périodique
Annales d'Endocrinologie
Auteur(s)
Arsenijevic Y., Aubert M.L.
ISSN
0003-4266
Statut éditorial
Publié
Date de publication
1990
Peer-reviewed
Oui
Volume
51
Numéro
2
Pages
65-71
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
The gonadotropin-releasing hormone (GnRH) controls LH and FSH secretion by membrane receptor interaction followed by a transmission mechanism involving Ca2+ secretion and phosphoinositides hydrolysis. In the first step, GnRH binds to its receptor and induces the formation of aggregates of a certain number of hormone-receptor complexes. Some of these GnRH-receptor complexes are internalized. Then, the receptors are either degraded in lysosomes or recycled through inclusion into secretory granules in the area of the Golgi. Note that receptor internalization is not necessary for the LH response to GnRH that intervenes immediately after GnRH binding to its receptor. Binding of GnRH to membrane receptors provokes extracellular calcium flux into the cell. At the same time, an increase in intracellular Ca2+ from non-mitochondrial stock is observed. Intracellular Ca2+ is important for the initiation of LH response and then extracellular Ca2+ is necessary for a sustained response. GnRH also stimulates phosphoinositides hydrolysis (probably mediated by a G-protein) inducing inositol 1,4,5-triphosphate liberation. This component would participate in Ca2+i increase necessary for the early LH response. Another hydrolysis product is diacylglycerol (DAG) that binds principally to protein kinase C (PKC). On the one hand, this complex can activate "masked" GnRH receptors and participate in this manner to an up-regulation. On the other hand, it seems that FSH beta mRNA expression depends on PKC. GnRH secretion rythm modulates alpha, LH beta and FSH beta subunits mRNA expression, and secretion of these hormones. PKC could be an important regulator of these functions. DAG can also induce LH secretion, this mechanism uses PKC activation and requires gonadotrophin neosynthesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals, Calcium/analysis, Calcium/physiology, Diglycerides/metabolism, Follicle Stimulating Hormone/secretion, Gonadotropin-Releasing Hormone/metabolism, Haplorhini, Humans, Luteinizing Hormone/secretion, Nerve Tissue Proteins/metabolism, Phosphatidylinositols/metabolism, Pituitary Gland, Anterior/chemistry, Pituitary Gland, Anterior/metabolism, Protein Kinase C/metabolism, Receptors, LHRH/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:31
Dernière modification de la notice
03/03/2018 21:21
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