Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_C8B58A407565
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.
Périodique
Frontiers in Microbiology
Auteur(s)
Lamoth F., Juvvadi P.R., Steinbach W.J.
ISSN
1664-302X (Electronic)
ISSN-L
1664-302X
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
6
Pages
96
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the emergence of resistance warrant the identification of new antifungal targets. Histone deacetylases (HDACs) are enzymes responsible of the deacetylation of lysine residues of core histones, thus controlling chromatin remodeling and transcriptional activation. HDACs also control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (Hsp90), an essential molecular chaperone for fungal virulence and antifungal resistance. This review provides an overview of the different HDACs in Aspergillus spp. as well as their respective contribution to total HDAC activity, fungal growth, stress responses, and virulence. The potential of HDAC inhibitors, currently under development for cancer therapy, as novel alternative antifungal agents against IA is discussed.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/03/2015 19:28
Dernière modification de la notice
09/05/2019 1:10
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