Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.

Details

Serval ID
serval:BIB_C8AD2E65514C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.
Journal
Journal of neurology, neurosurgery, and psychiatry
Author(s)
Tholance Y., Moritz C.P., Rosier C., Ferraud K., Lassablière F., Reynaud-Federspiel E., França M.C., Martinez ARM, Camdessanché J.P., Antoine J.C.
Working group(s)
anti-FGFR3 antibody Study Group
Contributor(s)
Adams D., Cauquil C., Attarian S., Delmont E., Blanchet-Fourcade G., Callias C., Cassereau J., Choumert A., Clavelou P., Créange A., Virgilio G.D., Echaniz-Laguna A., Faucher B., Galea I., Genestet S., Guéguen A., Ion I.M., Juntas-Morales R., Taieb G., Kuntzer T., Lagrange E., Léger J.M., Stojkovic T., Lepetit M., Magy L., Mas J., Michaud M., Mouthon-Reignier C., Neau J.P., Ozsancak C., Péréon Y., Perrotte P., Puma A., Rajabally Y.A., Rinaldi S., Rouaud V., Sole G., Tard C., Vallet A.E., Vial C.
ISSN
1468-330X (Electronic)
ISSN-L
0022-3050
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
91
Number
1
Pages
49-57
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN.
A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched').
Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424).
Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors.
Keywords
anti-FGFR3 autoantibodies, autoimmune diseases, fibroblast growth factor receptor 3 (FGFR3), sensory neuronopathies, sensory neuropathies
Pubmed
Web of science
Create date
07/02/2020 12:35
Last modification date
15/07/2020 6:26
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