Neuron death in the developing avian isthmo-optic nucleus, and its relation to the establishment of functional circuitry.

Détails

ID Serval
serval:BIB_C891689A0E9E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Neuron death in the developing avian isthmo-optic nucleus, and its relation to the establishment of functional circuitry.
Périodique
Journal of Neurobiology
Auteur(s)
Clarke P.G.H.
ISSN
0022-3034[print], 0022-3034[linking]
Statut éditorial
Publié
Date de publication
1992
Volume
23
Numéro
9
Pages
1140-1158
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review Comparative Study Journal Article Research Support, Non-U.S. Gov't Review --- Old month value: Nov
Résumé
The present review covers all the published data on neuron death in the developing avian isthmo-optic nucleus (ION), which provides a particularly convenient situation for studying the causes and consequences of neuron death in the development of the vertebrate central nervous system. The main conclusions are as follows: The naturally occurring neuron death in the ION is related both temporally and causally to the ION's formation of afferent and efferent connections. The ION neurons need to obtain both anterograde and retrograde survival signals in order to survive during a critical period in embryogenesis. They may compete, at least for the retrograde signals, but the nature of the competition is still unclear. The retrograde signals are modified by action potentials. Neurons dying from a lack of anterograde survival signals can be distinguished morphologically from ones dying from a lack of retrograde signals. The neuron death refines circuitry by selectively eliminating neurons with "aberrant" axons projecting to the "wrong" (i.e., ipsilateral) retina or to the "wrong" (topographically inappropriate) part of the contralateral retina.
Mots-clé
Animals, Axons/physiology, Cell Death/physiology, Chick Embryo, Efferent Pathways/cytology, Efferent Pathways/embryology, Neurons/cytology, Retina/embryology, Retina/physiology
Pubmed
Web of science
Création de la notice
20/01/2008 18:49
Dernière modification de la notice
03/03/2018 21:21
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