Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants.

Détails

ID Serval
serval:BIB_C8774961CAC0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants.
Périodique
Biomaterials
Auteur(s)
Majd H., Scherer S.S., Boo S., Ramondetti S., Cambridge E., Raffoul W., Friedrich M., Pittet B., Pioletti D., Hinz B., Pietramaggiori G.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
54
Pages
136-147
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Over the past decade, various implantable devices have been developed to treat diseases that were previously difficult to manage such diabetes, chronic pain, and neurodegenerative disorders. However, translation of these novel technologies into clinical practice is often difficult because fibrotic encapsulation and/or rejection impairs device function after body implantation. Ideally, cells of the host tissue should perceive the surface of the implant being similar to the normal extracellular matrix. Here, we developed an innovative approach to provide implant surfaces with adhesive protein micropatterns. The patterns were designed to promote adhesion of fibroblasts and macrophages by simultaneously suppressing fibrogenic activation of both cell types. In a rat model, subcutaneously implanted silicone pads provided with the novel micropatterns caused 6-fold lower formation of inflammatory giant cells compared with clinical grade, uncoated, or collagen-coated silicone implants. We further show that micropatterning of implants resulted in 2-3-fold reduced numbers of pro-fibrotic myofibroblast by inhibiting their mechanical activation. Our novel approach allows controlled cell attachment to implant surfaces, representing a critical advance for enhanced biointegration of implantable medical devices.
Pubmed
Web of science
Création de la notice
05/06/2015 17:11
Dernière modification de la notice
03/03/2018 21:21
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