Epigenetic regulation of the bacterial cell cycle.

Détails

ID Serval
serval:BIB_C83FABFCF4E1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Epigenetic regulation of the bacterial cell cycle.
Périodique
Current Opinion in Microbiology
Auteur(s)
Collier J.
ISSN
1879-0364[electronic], 1369-5274[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
12
Numéro
6
Pages
722-729
Langue
anglais
Résumé
N(6)-methyl-adenines can serve as epigenetic signals for interactions between regulatory DNA sequences and regulatory proteins that control cellular functions, such as the initiation of chromosome replication or the expression of specific genes. Several of these genes encode master regulators of the bacterial cell cycle. DNA adenine methylation is mediated by Dam in gamma-proteobacteria and by CcrM in alpha-proteobacteria. A major difference between them is that CcrM is cell cycle regulated, while Dam is active throughout the cell cycle. In alpha-proteobacteria, GANTC sites can remain hemi-methylated for a significant period of the cell cycle, depending on their location on the chromosome. In gamma-proteobacteria, most GATC sites are only transiently hemi-methylated, except regulatory GATC sites that are protected from Dam methylation by specific DNA-binding proteins.
Mots-clé
Adenine/analogs & derivatives, Adenine/metabolism, Alphaproteobacteria/physiology, Bacterial Proteins/metabolism, Cell Cycle, DNA, Bacterial/metabolism, Epigenesis, Genetic, Gammaproteobacteria/physiology, Gene Expression Regulation, Bacterial, Protein Binding, Site-Specific DNA-Methyltransferase (Adenine-Specific)/metabolism, Transcription Factors/metabolism
Pubmed
Web of science
Création de la notice
19/11/2009 11:31
Dernière modification de la notice
03/03/2018 21:21
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