Hyperpigmented small spots induced by long-term PUVA therapy. A clinical, light and electron microscopic study

Détails

ID Serval
serval:BIB_C82985F34EB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hyperpigmented small spots induced by long-term PUVA therapy. A clinical, light and electron microscopic study
Périodique
Dermatologica
Auteur(s)
Schneider  B., Vogel  A., Zisiadis  S., Panizzon  R., Groh  V.
ISSN
0011-9075 (Print)
Statut éditorial
Publié
Date de publication
10/1982
Volume
165
Numéro
4
Pages
330-41
Notes
Journal Article --- Old month value: Oct
Résumé
Among 308 photochemotherapy (PUVA)-treated patients, 15 psoriatics and 1 case of mycosis fungoides developed persistent disseminated hyperpigmented small spots at the trunk and limbs as a side effect of the therapy. The histological, histochemical and electron microscopical studies performed on 5 of the patients revealed a greatly increased number of melanocytes in the macules, hyperactivity of the melanocytes and increased transfer of pigment to dermis and keratinocytes. Moreover, binucleated cells were found as well as multifarious signs of melanocytic damage in varying degrees. Similar alterations but less pronounced were observed in the intermacular skin. Some of the changes could be recognized even 7 months after the treatment had been stopped. The PUVA spots are compared with other etiologically light-dependent hyperpigmentations.
Mots-clé
Adult Female Humans Male Microscopy, Electron Middle Aged PUVA Therapy/*adverse effects Photochemotherapy/*adverse effects Pigmentation Disorders/*chemically induced/pathology Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:43
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