Predicting Mortality After Transcatheter Aortic Valve Replacement: External Validation of the Transcatheter Valve Therapy Registry Model.

Détails

ID Serval
serval:BIB_C8017F897887
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Predicting Mortality After Transcatheter Aortic Valve Replacement: External Validation of the Transcatheter Valve Therapy Registry Model.
Périodique
Circulation. Cardiovascular interventions
Auteur(s)
Pilgrim T., Franzone A., Stortecky S., Nietlispach F., Haynes A.G., Tueller D., Toggweiler S., Muller O., Ferrari E., Noble S., Maisano F., Jeger R., Roffi M., Grünenfelder J., Huber C., Wenaweser P., Windecker S.
ISSN
1941-7632 (Electronic)
ISSN-L
1941-7640
Statut éditorial
Publié
Date de publication
11/2017
Peer-reviewed
Oui
Volume
10
Numéro
11
Pages
NA
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Validation Studies
Publication Status: ppublish
Résumé
The Transcatheter Valve Therapy (TVT) registry model was recently developed to predict the risk of in-hospital mortality in patients undergoing transcatheter aortic valve replacement. We sought to externally validate the model in an independent data set of consecutively enrolled patients in the Swiss Transcatheter Aortic Valve Implantation registry.
The original prediction model was retrospectively applied to 3491 consecutive patients undergoing transcatheter aortic valve replacement in Switzerland between February 2011 and February 2016. We examined model performance in terms of discrimination (Harrel C index) and calibration (Hosmer-Lemeshow goodness-of-fit test) for prediction of in-hospital and 30-day mortality and compared its predictive accuracy with the Society of Thoracic Surgeons Predicted Risk of Mortality score. Rates of in-hospital and 30-day mortality in the external validation cohort were 2.9% and 3.8%, respectively. The TVT registry model was found to have moderate discrimination (C index, 0.66; 95% confidence interval, 0.60-0.72 and C index, 0.67; 95% confidence interval, 0.62-0.72 for in-hospital and 30-day mortality, respectively) and good calibration. Compared with the Society of Thoracic Surgeons Predicted Risk of Mortality score, the TVT registry model demonstrated improved calibration for in-hospital (slope, 0.83; <i>P</i> =0.23 versus slope, 0.24; <i>P</i> <0.001, respectively) and 30-day (slope, 1.11; <i>P</i> =0.40 versus slope, 0.41; <i>P</i> <0.001, respectively) mortality.
In a large, multicenter, non-US cohort of patients with transcatheter aortic valve replacement, the validation of the TVT registry model demonstrated moderate discrimination and good calibration for the prediction of in-hospital and 30-day mortality. As a result, the TVT registry model should be considered an alternative to the Society of Thoracic Surgeons Predicted Risk of Mortality score for decision making and assessment of early outcome in patients eligible for transcatheter aortic valve replacement.
Mots-clé
Aged, Aged, 80 and over, Aortic Valve/surgery, Aortic Valve Stenosis/diagnosis, Aortic Valve Stenosis/mortality, Aortic Valve Stenosis/surgery, Area Under Curve, Decision Support Techniques, Female, Hospital Mortality, Humans, Male, Predictive Value of Tests, ROC Curve, Registries, Reproducibility of Results, Risk Assessment, Risk Factors, Switzerland, Time Factors, Transcatheter Aortic Valve Replacement/adverse effects, Transcatheter Aortic Valve Replacement/mortality, Treatment Outcome, decision making, humans, mortality, risk, transcatheter aortic valve replacement
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/11/2017 10:02
Dernière modification de la notice
20/08/2019 16:43
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