CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_C7F89A3A803E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CD160-Associated CD8 T-Cell Functional Impairment Is Independent of PD-1 Expression.
Périodique
Plos Pathogens
Auteur(s)
Viganò S., Banga R., Bellanger F., Pellaton C., Farina A., Comte D., Harari A., Perreau M.
ISSN
1553-7374 (Electronic)
ISSN-L
1553-7366
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
10
Numéro
9
Pages
e1004380
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Expression of co-inhibitory molecules is generally associated with T-cell dysfunction in chronic viral infections such as HIV or HCV. However, their relative contribution in the T-cell impairment remains unclear. In the present study, we have evaluated the impact of the expression of co-inhibitory molecules such as 2B4, PD-1 and CD160 on the functions of CD8 T-cells specific to influenza, EBV and CMV. We show that CD8 T-cell populations expressing CD160, but not PD-1, had reduced proliferation capacity and perforin expression, thus indicating that the functional impairment in CD160+ CD8 T cells may be independent of PD-1 expression. The blockade of CD160/CD160-ligand interaction restored CD8 T-cell proliferation capacity, and the extent of restoration directly correlated with the ex vivo proportion of CD160+ CD8 T cells suggesting that CD160 negatively regulates TCR-mediated signaling. Furthermore, CD160 expression was not up-regulated upon T-cell activation or proliferation as compared to PD-1. Taken together, these results provide evidence that CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression.
Pubmed
Web of science
Création de la notice
24/10/2014 13:40
Dernière modification de la notice
25/04/2018 16:03
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