Early effects of aldosterone on the basolateral potassium conductance of A6 cells

Détails

ID Serval
serval:BIB_C7DC01558614
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Early effects of aldosterone on the basolateral potassium conductance of A6 cells
Périodique
Pflügers Archiv : European Journal of Physiology
Auteur(s)
Broillet  M. C., Berger  A., Horisberger  J. D.
ISSN
0031-6768 (Print)
Statut éditorial
Publié
Date de publication
06/1993
Volume
424
Numéro
1
Pages
91-93
Résumé
Aldosterone increases the basolateral conductance in target epithelia. The basolateral membrane of tight epithelia contains two different types of K+ conductances (GK), a "resting" and a volume-activated GK. We have studied the early effects (at 4 hours) of 500 nmol/l aldosterone on the basolateral membrane GK of A6 cells (a Xenopus laevis kidney cell line), after the permeabilization of the apical membrane with amphotericin B. In the presence of a 97 to 3 mmol/l apical to basolateral K+ gradient, the "resting", inward rectifying GK was similar in control and aldosterone treated cells. In contrast, aldosterone induced a 2-fold increase of the volume-activated quinidine sensitive GK.
Mots-clé
Aldosterone/*pharmacology Amphotericin B/pharmacology Animals Cell Line Cell Membrane Permeability/drug effects Electric Conductivity Epithelium/drug effects/physiology Kidney/drug effects/*physiology Kinetics Potassium Channels/drug effects/*physiology Quinidine/pharmacology Xenopus laevis
Pubmed
Web of science
Création de la notice
24/01/2008 13:38
Dernière modification de la notice
03/03/2018 21:20
Données d'usage