Thymic MHC class I gene regulation of susceptibility to lymphocytic choriomeningitis

Détails

ID Serval
serval:BIB_C7948AA53AD9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Thymic MHC class I gene regulation of susceptibility to lymphocytic choriomeningitis
Périodique
Thymus
Auteur(s)
Speiser  D. E., Zinkernagel  R. M.
ISSN
0165-6090 (Print)
Statut éditorial
Publié
Date de publication
12/1990
Volume
16
Numéro
3-4
Pages
187-93
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov-Dec
Résumé
Susceptibility of mice to intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) depends on the LCMV isolate and host genes. We have previously shown that major histocompatibility complex (MHC) class I genes regulate susceptibility to lethal disease due to infection with the LCMV-docile isolate derived from the LCMV-UBC strain. The Dq allele conferred dominant susceptibility whereas other H-2D region alleles tested (Dd, Dk, Db and Ds) conferred resistance. Susceptibility linked to Dq correlated strongly with early and potent LCMV-specific cytotoxic T cell (CTL) activation responsible for the CTL mediated immunopathological disease. To assess the extent to which thymic MHC products control lethal LCM, two studies were performed. First, (H-2Dk x H-2Dq)F1 bone marrow stem cells were used to reconstitute lethally irradiated recipients of each parental type. Reconstituted H-2Dk hosts were found to be resistant whereas H-2Dq hosts were susceptible to lethal LCM after i.c. infection, indicating that the phenotype of disease susceptibility was determined by the host. Second, we investigated the role of the thymus in the determination of resistance or susceptibility to LCM. Previously thymectomized (H-2Dk x H-2Dq)F1 mice received a thymus graft from either H-2Dk or H-2Dq fetal mice. After differentiation of F1 lymphoid precursor cells in the implanted thymus, susceptibility to lethal LCM was assessed. F1 recipient mice carrying a thymus expressing Dk were resistant whereas those carrying a thymus expressing Dq were susceptible. Therefore, as an extension of various previous studies on T cell immune responses, our results document directly that disease susceptibility to lethal LCM is controlled by MHC class I molecules of the thymus.
Mots-clé
Animals Gene Expression Regulation *Genes, MHC Class I H-2 Antigens/genetics Lymphocytic Choriomeningitis/genetics/*immunology Mice Mice, Inbred Strains Radiation Chimera T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
03/03/2018 21:19
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