Article: article from journal or magazin.
Inhibitory effect of neuropeptide Y on stimulated renin secretion of awake rats.
Clinical and experimental pharmacology & physiology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
1. (1-36)-NPY is a vasoconstrictor peptide widely distributed in sympathetic nerve terminals. This peptide exerts an inhibitory action on renin release induced by various stimuli. Post-synaptic neuropeptide Y (NPY) receptors show a high affinity for (1-36)-NPY as well as for the agonist (Pro34)-NPY, while presynaptic receptors bind preferentially (13-36)-NPY. 2. This study was undertaken to assess whether the NPY induced renin suppression in awake normotensive rats infused with the beta-adrenoceptor stimulant isoproterenol is mediated by activation of pre- or post-synaptic receptors. 3. Non-pressor doses of (1-36)-NPY and (Pro34)-NPY markedly attenuated the renin secretion triggered by isoproterenol whereas (13-36)-NPY had no effect. This suggests that the effect of NPY on renin release is due to the stimulation of post-synaptic receptors. However it remains unknown whether NPY acts directly on juxtaglomerular cells or indirectly by modifying intraglomerular haemodynamics.
Animals, Blood Pressure, Heart Rate, Isoproterenol, Male, Neuropeptide Y, Peptide Fragments, Rats, Rats, Inbred Strains, Receptors, Neuropeptide Y, Receptors, Neurotransmitter, Renin
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