Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand.

Details

Serval ID
serval:BIB_C75187DC6101
Type
Article: article from journal or magazin.
Collection
Publications
Title
Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand.
Journal
Journal of Experimental Medicine
Author(s)
Ito T., Yang M., Wang Y.H., Lande R., Gregorio J., Perng O.A., Qin X.F., Liu Y.J., Gilliet M.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
2007
Volume
204
Number
1
Pages
105-115
Language
english
Notes
Publication types: In Vitro ; Journal Article
Publication Status: ppublish
Abstract
Although there is evidence for distinct roles of myeloid dendritic cells (DCs [mDCs]) and plasmacytoid pre-DCs (pDCs) in regulating T cell-mediated adaptive immunity, the concept of functional DC subsets has been questioned because of the lack of a molecular mechanism to explain these differences. In this study, we provide direct evidence that maturing mDCs and pDCs express different sets of molecules for T cell priming. Although both maturing mDCs and pDCs upregulate the expression of CD80 and CD86, only pDCs upregulate the expression of inducible costimulator ligand (ICOS-L) and maintain high expression levels upon differentiation into mature DCs. High ICOS-L expression endows maturing pDCs with the ability to induce the differentiation of naive CD4 T cells to produce interleukin-10 (IL-10) but not the T helper (Th)2 cytokines IL-4, -5, and -13. These IL-10-producing T cells are T regulatory cells, and their generation by ICOS-L is independent of pDC-driven Th1 and Th2 differentiation, although, in the later condition, some contribution from endogenous IL-4 cannot be completely ruled out. Thus, in contrast to mDCs, pDCs are poised to express ICOS-L upon maturation, which leads to the generation of IL-10-producing T regulatory cells. Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses.
Keywords
Adult, Antigens, CD, Cell Differentiation, Dendritic Cells/classification, Dendritic Cells/immunology, Humans, Inducible T-Cell Co-Stimulator Ligand, Interleukin-10/biosynthesis, Myeloid Cells/classification, Myeloid Cells/immunology, Plasma Cells/classification, Plasma Cells/immunology, Proteins/metabolism, T-Lymphocytes, Regulatory/immunology, Th2 Cells/immunology, Up-Regulation
Pubmed
Web of science
Open Access
Yes
Create date
23/03/2012 12:02
Last modification date
20/08/2019 15:42
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