The habenula encodes negative motivational value associated with primary punishment in humans.

Détails

ID Serval
serval:BIB_C7380B2692E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The habenula encodes negative motivational value associated with primary punishment in humans.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Lawson R.P., Seymour B., Loh E., Lutti A., Dolan R.J., Dayan P., Weiskopf N., Roiser J.P.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
111
Numéro
32
Pages
11858-11863
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.
Mots-clé
Adult, Animals, Conditioning (Psychology), Cues, Female, Functional Neuroimaging, Habenula/anatomy & histology, Habenula/physiology, Humans, Learning/physiology, Magnetic Resonance Imaging, Male, Motivation/physiology, Punishment/psychology, Reinforcement (Psychology), Species Specificity, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/10/2014 11:00
Dernière modification de la notice
09/05/2019 1:05
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