Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis

Détails

ID Serval
serval:BIB_C727B6613702
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis
Périodique
Biochemical and Biophysical Research Communications
Auteur(s)
Delforge  D., Depiereux  E., De Bolle  X., Feytmans  E., Remacle  J.
ISSN
0006-291X (Print)
Statut éditorial
Publié
Date de publication
02/1993
Volume
190
Numéro
3
Pages
1073-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Résumé
Recent developments in simultaneous multiple alignment methods of protein sequences allow prediction of structural similarity in related proteins. Alanine dehydrogenase and the N-terminal sequence of pyridine nucleotide transhydrogenase were compared for their sequences. High similarities of sequences were observed especially in their NAD(H)-binding sites. These similarities suggest that antibodies which recognized the alanine dehydrogenase of Mycobacterium tuberculosis can also be directed against the membrane bound pyridine nucleotide transhydrogenase. If this is the case, the virulent property of this pathogen could be linked to its higher synthesis of NADPH necessary for its anabolism.
Mots-clé
Alanine Dehydrogenase Amino Acid Oxidoreductases/*chemistry Amino Acid Sequence Bacillus/enzymology Bacillus stearothermophilus/enzymology Molecular Sequence Data Mycobacterium tuberculosis/*enzymology NADP Transhydrogenase/*chemistry Sequence Alignment
Pubmed
Web of science
Création de la notice
28/01/2008 12:03
Dernière modification de la notice
03/03/2018 21:19
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