CoevDB: a database of intramolecular coevolution among protein-coding genes of the bony vertebrates.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_C6FD42281624
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
CoevDB: a database of intramolecular coevolution among protein-coding genes of the bony vertebrates.
Périodique
Nucleic Acids Research
Auteur(s)
Meyer X., Dib L., Salamin N.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
47
Numéro
D1
Pages
D50-D54
Langue
anglais
Résumé
The study of molecular coevolution, due to its potential to identify gene regions under functional or structural constraints, has recently been subject to numerous scientific inquiries. Particular efforts have been conducted to develop methods predicting the presence of coevolution in molecular sequences. Among these methods, a few aim to model the underlying evolutionary process of coevolution, which enable to differentiate the shared history of genes to coevolution and thus improve their accuracy. However, the usage of such methods remains sparse due to their expensive computational cost and the lack of resources alleviating this issue. Here we present CoevDB (http://phylodb.unil.ch/CoevDB), a database containing the result of a large-scale analysis of intramolecular coevolution of 8201 protein-coding genes of bony vertebrates. The web interface of CoevDB gives access to the results to 800 millions of statistical tests corresponding to all the pairs of sites analyzed. Several type of queries enable users to explore the database by either targeting specific genes or by discovering genes having promising estimations of coevolution.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/11/2018 9:39
Dernière modification de la notice
09/05/2019 1:04
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