Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration.

Détails

ID Serval
serval:BIB_C6BB160440A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration.
Périodique
Archives of virology
Auteur(s)
Ramirez J.C., Finke D., Esteban M., Kraehenbuhl J.P., Acha-Orbea H.
ISSN
0304-8608
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
148
Numéro
5
Pages
827-39
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
MVA is a candidate vector for vaccination against pathogens and tumors. Little is known about its behaviour in mucosal tissues. We have investigated the fate and biosafety of MVA, when inoculated by different routes in C57BL/6 mice. Intranasal inoculation targeted the virus to the nasal associated lymphoid tissue and the lungs, whereas systemic inoculation led to distribution of MVA in almost all lymphoid organs, lungs and ovaries. Intravaginal, intrarectal and intragastric inoculations failed to induce efficient infection. After 48 h no virus was detectable any more in the organs analyzed. Upon intranasal inoculation, no inflammatory reactions were detected in the central nervous system as well as the upper and lower airways. These results show the tropism of MVA and indicate that high doses of recombinant MVA are safe when nasally administered, a vaccination route known to elicit strong cellular and humoral immune responses in the female genital tract.
Mots-clé
Administration, Intranasal, Animals, Brain, Digestive System, Female, Genitalia, Female, Immunity, Mucosal, Lung, Lymph Nodes, Mice, Mice, Inbred C57BL, Mucous Membrane, Respiratory System, Vaccines, Vaccinia virus
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 21:18
Données d'usage