Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.

Détails

ID Serval
serval:BIB_C69D0561EF9D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
Périodique
Plos One
Auteur(s)
Lingappa J.R., Petrovski S., Kahle E., Fellay J., Shianna K., McElrath M.J., Thomas K.K., Baeten J.M., Celum C., Wald A., de Bruyn G., Mullins J.I., Nakku-Joloba E., Farquhar C., Essex M., Donnell D., Kiarie J., Haynes B., Goldstein D.
Collaborateur(s)
Partners in Prevention HSV/HIV Transmission Study Team
Contributeur(s)
Celum C., Wald A., Lingappa JR., Baeten JM., Campbell MS., Corey L., Coombs RW., Hughes JP., Magaret A., McElrath M., Morrow R., Mullins JI., Africa S., Coetzee D., Fife K., Were E., Essex M., Makhema J., Katabira E., Ronald A., Bukusi E., Cohen C., Kapiga S., Manongi R., Farquhar C., John-Stewart G., Kiarie J., Africa S., Delany-Moretlwe S., Rees H., Africa S., de Bruyn G., Gray G., McIntyre J., Mugo NR.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2011
Volume
6
Numéro
12
Pages
e28632
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use.
METHODS: We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfected individuals was performed to identify factors associated with HIV-1 acquisition. In addition, a linear regression analysis was performed using SNP data from a subset (n = 403) of HIV-1 infected individuals to identify factors predicting plasma HIV-1 concentrations.
RESULTS: After correcting for multiple comparisons, no SNPs were significantly associated with HIV-1 infection status or plasma HIV-1 concentrations.
CONCLUSION: This GWAS controlling for HIV-1 exposure did not identify common host genotypes influencing HIV-1 acquisition. Alternative strategies, such as large-scale sequencing to identify low frequency variation, should be considered for identifying novel host genetic predictors of HIV-1 acquisition.
Mots-clé
Adolescent, Adult, Africa, Eastern/epidemiology, Aged, Family Characteristics, Female, Genetic Variation, Genome-Wide Association Study, Genotype, HIV Infections/epidemiology, HIV Infections/genetics, HIV Seropositivity/immunology, HIV Seropositivity/virology, HIV-1/immunology, Humans, Male, Middle Aged, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2012 16:14
Dernière modification de la notice
09/05/2019 1:03
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