Improved General and Height-Specific Quality of Life in Children With Short Stature After 1 Year on Growth Hormone.

Details

Serval ID
serval:BIB_C666CE15ED46
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Improved General and Height-Specific Quality of Life in Children With Short Stature After 1 Year on Growth Hormone.
Journal
The Journal of clinical endocrinology and metabolism
Author(s)
González Briceño L.G., Viaud M., Beltrand J., Flechtner I., Dassa Y., Samara-Boustani D., Thalassinos C., Pauwels C., Busiah K., Pinto G., Jaquet D., Polak M.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Publication state
Published
Issued date
01/06/2019
Peer-reviewed
Oui
Volume
104
Number
6
Pages
2103-2111
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Short stature in children and adolescents may lead to social and emotional stress, with negative effects on quality of life (QoL). GH treatment may improve QoL through height normalization. Our objective here was to evaluate general and height-specific QoL after 1 year of GH treatment.
Prospective, single-center, observational cohort study.
Children ≥ 4 years of age starting GH at our center from 2012 to 2015 to treat short stature were studied. Patients with serious diseases, syndromic short stature, or developmental delay were excluded. At treatment initiation and 1 year later, patients and their parents completed the general PedsQL 4.0 and height-specific Quality of Life in Short Stature Youth (QoLiSSY) questionnaires. Correlations between self-report and parent-report scores and between height gain and QoL improvements were assessed based on Pearson correlation coefficients.
Seventy-four children (42 boys, 32 girls), median age (± SD), 10.2 ± 3.0 years (range, 4.1 to 16.6 years), were included. The self-report PedsQL indicated significant improvements in emotional (P = 0.02) and social (P = 0.03) QoL. As assessed by the QoLiSSY, children reported improvement of social QoL (+0.2 SD; P = 0.04), and parents reported improvement of children's physical (+0.1 SD; P < 0.0001), emotional (+0.3 SD; P < 0.0001), and social (+0.3 SD; P < 0.0001) QoL. Height SD score (SDS) gains showed moderate positive correlations with QoLISSY self-report score gains (R = 0.53, R2 = 0.28; P < 0.001) and QoLISSY parent-report gains (R = 0.60, R2 = 0.41; P < 0.00001).
After 1 year of GH treatment, children had significant gains in emotional and social QoL, as assessed by a general self-report questionnaire and height-specific parent-report questionnaire.
Keywords
Adolescent, Body Height, Child, Child, Preschool, Emotions, Female, Growth Disorders/drug therapy, Growth Disorders/psychology, Human Growth Hormone/therapeutic use, Humans, Male, Prospective Studies, Quality of Life, Self Report
Pubmed
Web of science
Open Access
Yes
Create date
08/02/2019 12:52
Last modification date
03/05/2020 6:02
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