Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.

Détails

ID Serval
serval:BIB_C64A1880105A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Périodique
Nature cell biology
Auteur(s)
Fumagalli F., Noack J., Bergmann T.J., Cebollero E., Pisoni G.B., Fasana E., Fregno I., Galli C., Loi M., Soldà T., D'Antuono R., Raimondi A., Jung M., Melnyk A., Schorr S., Schreiber A., Simonelli L., Varani L., Wilson-Zbinden C., Zerbe O., Hofmann K., Peter M., Quadroni M., Zimmermann R., Molinari M.
ISSN
1476-4679 (Electronic)
ISSN-L
1465-7392
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
18
Numéro
11
Pages
1173-1184
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzymes to reduce the burden of misfolded proteins. On resolution of ER stress, ill-defined, selective autophagic programs remove excess ER components. Here we identify Sec62, a constituent of the translocon complex regulating protein import in the mammalian ER, as an ER-resident autophagy receptor. Sec62 intervenes during recovery from ER stress to selectively deliver ER components to the autolysosomal system for clearance in a series of events that we name recovER-phagy. Sec62 contains a conserved LC3-interacting region in the C-terminal cytosolic domain that is required for its function in recovER-phagy, but is dispensable for its function in the protein translocation machinery. Our results identify Sec62 as a critical molecular component in maintenance and recovery of ER homeostasis.

Mots-clé
Animals, Autophagy, Endoplasmic Reticulum/metabolism, Endoplasmic Reticulum Stress/physiology, Homeostasis, Humans, Membrane Transport Proteins/metabolism, Mice, Molecular Chaperones/metabolism, Protein Biosynthesis/physiology, Protein Transport/physiology, Unfolded Protein Response/physiology
Pubmed
Création de la notice
01/12/2016 10:49
Dernière modification de la notice
03/03/2018 21:17
Données d'usage