The evolution of lncRNA repertoires and expression patterns in tetrapods.

Détails

ID Serval
serval:BIB_C6378882D5BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The evolution of lncRNA repertoires and expression patterns in tetrapods.
Périodique
Nature
Auteur(s)
Necsulea A., Soumillon M., Warnefors M., Liechti A., Daish T., Zeller U., Baker J.C., Grützner F., Kaessmann H.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2014
Volume
505
Numéro
7485
Pages
635-640
Langue
anglais
Résumé
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. We identify approximately 11,000 primate-specific lncRNAs and 2,500 highly conserved lncRNAs, including approximately 400 genes that are likely to have originated more than 300 million years ago. We find that lncRNAs, in particular ancient ones, are in general actively regulated and may function predominantly in embryonic development. Most lncRNAs evolve rapidly in terms of sequence and expression levels, but tissue specificities are often conserved. We compared expression patterns of homologous lncRNA and protein-coding families across tetrapods to reconstruct an evolutionarily conserved co-expression network. This network suggests potential functions for lncRNAs in fundamental processes such as spermatogenesis and synaptic transmission, but also in more specific mechanisms such as placenta development through microRNA production.
Mots-clé
Animals, Anura/genetics, Chickens/genetics, Conserved Sequence/genetics, Evolution, Molecular, Gene Expression Regulation, Developmental/genetics, Genomics, Humans, Mice, MicroRNAs/genetics, Multigene Family, Primates/genetics, Proteins/genetics, RNA Precursors/genetics, RNA, Long Noncoding/genetics, Transcriptome
Pubmed
Web of science
Création de la notice
24/02/2014 11:52
Dernière modification de la notice
03/03/2018 21:17
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