Bullous pemphigoid is the most frequent autoimmune bullous dermatosis. Cases induced by immune checkpoint inhibitors have been described. This antitumor immunotherapy changed the treatment of several malignant tumors, especially melanoma and non-small cell lung-cancer. Nevertheless, immune adverse events are common. We present a case of bullous pemphigoid induced by pembrolizumab to illustrate the link between this disease and the treatment with immune checkpoint inhibitors.