Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia

Détails

ID Serval
serval:BIB_C624F99C8A0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia
Périodique
Journal of Infectious Diseases
Auteur(s)
Bille  J., Glauser  M. P.
ISSN
0022-1899
Statut éditorial
Publié
Date de publication
08/1982
Peer-reviewed
Oui
Volume
146
Numéro
2
Pages
220-6
Langue
anglais
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
licence nationale
Résumé
Previous experiments in rats have suggested that renal scarring after acute, obstructive pyelonephritis due to Escherichia coli results from parenchymal damage due to acute inflammation and suppuration. To assess the role of acute infiltration by polymorphonuclear leukocytes (PMNLs) in the pathogenesis of chronic pyelonephritis (CPN), rats were either treated with colchicine to depress leukocyte motility or rendered neutropenic with a single dose of cyclophosphamide. Colchicine given during acute pyelonephritis reduced kidney inflammation and protected against CPN two months later. Similarly, neutropenia reduced acute inflammation and protected against chronic parenchymal destruction and scarring. Protection against renal scarring in both colchicine-treated and neutropenic rats occurred despite higher renal bacterial counts during acute pyelonephritis. These experiments provide further evidence that CPN (renal scarring) results from kidney damage that occurs during early acute obstructive pyelonephritis. This damage appears to result from infiltration of the kidney by PMNLs rather than direct damage from bacterial infection.
Mots-clé
Abscess/etiology Animals Colchicine/pharmacology Cyclophosphamide/pharmacology Kidney/pathology Male Neutropenia Neutrophils/*physiology Pyelonephritis/*etiology/pathology Rats Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
11/02/2008 13:39
Dernière modification de la notice
18/07/2018 16:03
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