Dopamine, paranormal belief, and the detection of meaningful stimuli

Details

Serval ID
serval:BIB_C5E9DBB816DB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dopamine, paranormal belief, and the detection of meaningful stimuli
Journal
Journal of Cognitive Neuroscience
Author(s)
Krummenacher P., Mohr C., Haker H., Brugger P.
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
22
Number
8
Pages
1670-1681
Language
english
Notes
1530-8898 (Electronic)
0898-929X (Linking)
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Abstract
Dopamine (DA) is suggested to improve perceptual and cognitive decisions by increasing the signal-to-noise ratio. Somewhat paradoxically, a hyperdopaminergia (arguably more accentuated in the right hemisphere) has also been implied in the genesis of unusual experiences such as hallucinations and paranormal thought. To test these opposing assumptions, we used two lateralized decision tasks, one with lexical (tapping left-hemisphere functions), the other with facial stimuli (tapping right-hemisphere functions). Participants were 40 healthy right-handed men, of whom 20 reported unusual, "paranormal" experiences and beliefs ("believers"), whereas the remaining participants were unexperienced and critical ("skeptics"). In a between-subject design, levodopa (200 mg) or placebo administration was balanced between belief groups (double-blind procedure). For each task and visual field, we calculated sensitivity (d') and response tendency (criterion) derived from signal detection theory. Results showed the typical right visual field advantage for the lexical decision task and a higher d' for verbal than facial stimuli. For the skeptics, d' was lower in the levodopa than in the placebo group. Criterion analyses revealed that believers favored false alarms over misses, whereas skeptics displayed the opposite preference. Unexpectedly, under levodopa, these decision preferences were lower in both groups. We thus infer that levodopa (1) decreases sensitivity in perceptual-cognitive decisions, but only in skeptics, and (2) makes skeptics less and believers slightly more conservative. These results stand at odd to the common view that DA generally improves signal-to-noise ratios. Paranormal ideation seems an important personality dimension and should be assessed in investigations on the detection of signals in noise.
Keywords
Adult Analysis of Variance Chi-Square Distribution *Culture Decision Making/drug effects Dopamine/*metabolism Dopamine Agents/blood/pharmacology Double-Blind Method Functional Laterality/drug effects/physiology Humans Levodopa/blood/pharmacology Male Motor Skills/drug effects/physiology Neuropsychological Tests Paranoid Personality Disorder/*psychology Pattern Recognition, Visual/drug effects/physiology Photic Stimulation/methods Questionnaires Reaction Time/drug effects/physiology Signal Detection, Psychological/drug effects/*physiology Thinking/drug effects/*physiology Visual Fields/drug effects/physiology Young Adult
Create date
17/01/2011 19:07
Last modification date
20/08/2019 15:41
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