Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.

Détails

ID Serval
serval:BIB_C5DE50D498E3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.
Périodique
Human pathology
Auteur(s)
Sempoux C., Bisig B., Couchy G., Balabaud C., Zucman-Rossi J., Bioulac-Sage P.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
62
Pages
122-125
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
In 1984, a 24-year-old woman underwent a right hepatectomy after a 17-cm nodule, diagnosed as a hepatocellular adenoma with some atypia. The resection was incomplete. Follow-up was interrupted. In 1996, a computed tomographic scan revealed a large multifocal hepatocellular carcinoma confirmed on biopsies. The patient died the same year. We reviewed these nodules using immunohistochemistry and gene sequencing. C-reactive protein was overexpressed in the tumor resected in 1984. Glutamine synthetase was heterogeneous in the tumor, with a few tumor nuclei expressing β-catenin. Glypican and heat shock protein 70 were negative. In this β-catenin-activated inflammatory hepatocellular adenoma, S45 β-catenin-activating mutation was detected on fixed tissue, embedded in paraffin without TERT promoter mutation. An identical CTNNB1 mutation was identified in the 1996 liver tumor together with a TERT promoter mutation showing that this hepatocellular carcinoma results from the malignant transformation of the initial β-catenin inflammatory adenoma.

Mots-clé
Adenoma/genetics, Adenoma/pathology, Adenoma/surgery, Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Biopsy, Carcinoma, Hepatocellular/drug therapy, Carcinoma, Hepatocellular/genetics, Carcinoma, Hepatocellular/pathology, Cell Transformation, Neoplastic/genetics, Cell Transformation, Neoplastic/pathology, DNA Mutational Analysis, Fatal Outcome, Female, Hepatectomy, Humans, Immunochemistry, Liver Neoplasms/drug therapy, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Liver Neoplasms/surgery, Mutation, Neoplasm, Residual, Time Factors, Treatment Outcome, Young Adult, beta Catenin/genetics
Pubmed
Web of science
Création de la notice
20/12/2016 10:01
Dernière modification de la notice
03/03/2018 21:16
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