Nuclear medicine procedures in the diagnosis and therapy of medullary thyroid carcinoma.

Détails

ID Serval
serval:BIB_C5DA5AADB4E5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Nuclear medicine procedures in the diagnosis and therapy of medullary thyroid carcinoma.
Périodique
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Auteur(s)
Rufini V., Castaldi P., Treglia G., Perotti G., Gross M.D., Al-Nahhas A., Rubello D.
ISSN
0753-3322 (Print)
ISSN-L
0753-3322
Statut éditorial
Publié
Date de publication
03/2008
Peer-reviewed
Oui
Volume
62
Numéro
3
Pages
139-146
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating in the parafollicular cells (C cells) of the thyroid and secretes both calcitonin and carcino-embryonic antigen (CEA). Genetic and biochemical testing allow early pre-clinical identification of familial forms. Sporadic MTC usually presents as a solitary thyroid nodule; the diagnosis can be made preoperatively by fine-needle aspiration or by calcitonin assay, though it is usually established at the time of surgery. In the diagnostic assessment of MTC, nuclear medicine imaging provides its contribution mainly in the post-operative work-up to detect residual/recurrent tumor. For such purpose a number of radiopharmaceuticals, which take advantage of the specific expression of receptors (the somatostatin analogue (111)In-octreotide), hormone transporters (radiolabelled MIBG) or molecular targets (radiolabelled anti-CEA monoclonal antibodies) by MTC lesions are available; these tracers may be used also for the palliative treatment of advanced MTC. Interesting perspectives for MTC imaging are offered by PET radiopharmaceuticals.

Mots-clé
3-Iodobenzylguanidine, Animals, Carcinoembryonic Antigen/immunology, Carcinoma, Medullary/diagnostic imaging, Carcinoma, Medullary/radiotherapy, Humans, Iodine Radioisotopes, Nuclear Medicine, Positron-Emission Tomography, Radiopharmaceuticals/therapeutic use, Somatostatin/analogs & derivatives, Somatostatin/pharmacology, Thyroid Neoplasms/diagnostic imaging, Thyroid Neoplasms/radiotherapy, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
20/08/2017 22:27
Dernière modification de la notice
03/03/2018 21:16
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