Hematopoietic stem cell niches

Détails

ID Serval
serval:BIB_C5D9E0F8B322
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Titre
Hematopoietic stem cell niches
Titre du livre
Molecular Basis of Hematopoiesis
Auteur(s)
Wilson A., Trumpp A.
Editeur
Springer
Lieu d'édition
New York
ISBN
978-0-387-85815-9
Statut éditorial
Publié
Date de publication
2009
Editeur scientifique
Wickrema A., Kee B.
Numéro de chapitre
3
Pages
47-71
Langue
anglais
Résumé
The hematopoietic stem cell (HSC) is probably the best characterized somatic stem cell and is still the only one regularly used in clinical practice. Nevertheless, expansion of HSCs in vitro has been surprisingly unsuccessful, limiting their full therapeutic potential. During homeostasis, the vast majority of HSCs are found in the bone marrow (BM) localized to specific microenvironments called stem cell "niches." Over the last few years our knowledge of cellular niche components and the signaling molecules that coordinate the crosstalk between HSCs and niche cells has dramatically increased. Here we review the two main niche types found in the BM: the endosteal and the vascular niches, and provide an overview of the different signaling and cell adhesion molecules that form the HSC-niche synapse. Signals from BM niches not only control HSC dormancy, but also regulate the balance between self-renewal and differentiation. In the future, successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem cell-niche unit.
Création de la notice
15/04/2013 14:44
Dernière modification de la notice
20/08/2019 15:41
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