Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors.

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Ressource 1Télécharger: serval:BIB_C5D5CDA44B37.P001 (288.73 [Ko])
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ID Serval
serval:BIB_C5D5CDA44B37
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors.
Périodique
Annals of Oncology
Auteur(s)
Krieg A.H., Hefti F., Speth B.M., Jundt G., Guillou L., Exner U.G., von Hochstetter A.R., Cserhati M.D., Fuchs B., Mouhsine E., Kaelin A., Klenke F.M., Siebenrock K.A.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Statut éditorial
Publié
Date de publication
2011
Volume
22
Numéro
2
Pages
458-467
Langue
anglais
Résumé
Background: Synovial sarcoma (SS) is a malignant soft tissue sarcoma with a poor prognosis because of late local recurrence and distant metastases. To our knowledge, no studies have minimum follow-up of 10 years that evaluate long-term outcomes for survivors.
Patients and methods: Data on 62 patients who had been treated for SS from 1968 to 1999 were studied retrospectively in a multicenter study. Mean follow-up of living patients was 17.2 years and of dead patients 7.7 years.
Results: Mean age at diagnosis was 35.4 years (range 6-82 years). Overall survival was 38.7%. The 5-year survival was 74.2%; 10-year survival was 61.2%; and 15-year survival was 46.5%. Fifteen patients (24%) died of disease after 10 years of follow-up. Local recurrence occurred after a mean of 3.6 years (range 0.5-14.9 years) and metastases at a mean of 5.7 years (range 0.5-16.3 years). Only four patients were treated technically correctly with a planned biopsy followed by a wide resection or amputation. Factors associated with significantly worse prognosis included larger tumor size, metastases at the time of diagnosis, high-grade histology, trunk-related disease, and lack of wide resection as primary surgical treatment.
Conclusions: In SS, metastases develop late with high mortality. Patients with SS should be followed for >10 years.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/03/2011 9:44
Dernière modification de la notice
25/09/2019 7:10
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