The neurochemical profile quantified by in vivo 1H NMR spectroscopy.

Détails

ID Serval
serval:BIB_C5CC94691258
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The neurochemical profile quantified by in vivo 1H NMR spectroscopy.
Périodique
Neuroimage
Auteur(s)
Duarte J.M., Lei H., Mlynárik V., Gruetter R.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2012
Volume
61
Numéro
2
Pages
342-362
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish. PDF type: Review
Résumé
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.
Mots-clé
Animals, Blood-Brain Barrier/anatomy & histology, Blood-Brain Barrier/physiology, Brain/physiology, Brain/physiopathology, Brain Chemistry, Brain Neoplasms/metabolism, Brain Neoplasms/pathology, Cell Proliferation, Electromagnetic Fields, Humans, Magnetic Resonance Spectroscopy/instrumentation, Magnetic Resonance Spectroscopy/methods, Membrane Lipids/metabolism, Nervous System Diseases/diagnosis, Neurotransmitter Agents/metabolism, Species Specificity, Translational Medical Research
Pubmed
Web of science
Création de la notice
29/04/2013 10:41
Dernière modification de la notice
03/03/2018 21:16
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