The future of primary care structures will be interprofessional or it will not be! Beyond this somewhat provocative statement, this is, in fact, a transformation that is already on the way in Western countries. This article describes developments in different countries, such as the United States, where Patient-Centered Medical Homes, based on multi-professional teams, have been developing since the 2000s, and Canada, where the evolution of financial models is accompanying that of organizational models. In Europe, two examples of integration of the health and social domains highlight the relevance of such an approach in primary care.