Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Reversible emetine-induced myopathy with ECG abnormalities: a toxic myopathy
Journal of Neurology
Case Reports Journal Article --- Old month value: May
A young anorexic woman is described with a history of progressive muscle weakness following chronic ingestion of syrup of ipecac that was used in an attempt at weight control. Electrocardiogram (ECG) showed T-wave inversion in all leads and prolongation of the Q-T interval. Electromyography was abnormal. Muscle biopsy revealed a randomized, generalized, predominantly type-2 fibre atrophy and structural alterations in oxidative enzyme stains, such as targetoid and moth-eaten fibres. A few necrotic cells were actively phagocytosed. Electron microscopy revealed severe sarcomeric abnormalities with Z-line streaming, myofibrillar disorganization and increased lysosomal activity. After discontinuation of ipecac syrup, the patient noted a gradual improvement in her condition. The ECG became normal. Emetine and related drug-induced myopathies are uncommon but are of experimental interest because of their effects on mitochondria and the light they shed on autophagic mechanisms in muscle.
Adult Cardiomyopathies/chemically induced Electrocardiography Emetine/*toxicity Female Humans Microscopy, Electron Muscles/ultrastructure Neuromuscular Diseases/*chemically induced Time Factors
Web of science
Last modification date