Incorporation and washout of n-3 PUFA after high dose intravenous and oral supplementation in healthy volunteers.

Détails

ID Serval
serval:BIB_C537D1C57965
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Incorporation and washout of n-3 PUFA after high dose intravenous and oral supplementation in healthy volunteers.
Périodique
Clinical nutrition
Auteur(s)
Delodder F., Tappy L., Liaudet L., Schneiter P., Perrudet C., Berger M.M.
ISSN
1532-1983 (Electronic)
ISSN-L
0261-5614
Statut éditorial
Publié
Date de publication
06/2015
Peer-reviewed
Oui
Volume
34
Numéro
3
Pages
400-408
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Although the physiological effects of n-3 polyunsaturated fatty acids (n-3PUFA) are generally thought to require several weeks of exposure to allow their incorporation into plasma membranes, intravenous (IV) n-3PUFA attenuate the cardiovascular and neuroendocrine response to stress within 3 h. Whether oral n-3 PUFA exert similar early effects remains unknown.
To assess whether acute IV or short term oral n-3PUFA administration reproduces the metabolic effects of long term oral supplements during exercise, and how it relates to their incorporation into platelets and red blood cells (RBC) membranes.
Prospective single center open label study in 8 healthy subjects receiving a 3-h infusion of 0.6 g/kg body weight n-3PUFA emulsion, followed one week later by an oral administration of 0.6 g/kg over 3 consecutive days. Maximal power output (cycling exercise), maximal heart rate (HR), blood lactate at exhaustion, and platelet function were measured at baseline and after IV or 3-day oral supplementation; platelet and RBC membrane composition were assessed until 15 days after n-3PUFA administration.
Both IV and oral n-3PUFA significantly decreased maximal HR (-6% and -5%), maximal power output (-10%) and peak blood lactate (-47% and -52%) Platelet function tests were unchanged. The EPA and DHA membrane contents of RBC and platelets increased significantly, but only to 1.7-1.9% of fatty acid content.
The cardiovascular and metabolic effects of n-3 PUFA during exercise occur already within 1-3 days of exposure, and may be unrelated to changes in membranes composition. Effects occur within hours of administration and are unrelated to lipid membrane composition. Trial registered at clinicaltrials.gov as NCT00516178.

Mots-clé
Administration, Intravenous, Administration, Oral, Adult, Aged, Aged, 80 and over, Blood Platelets/drug effects, Blood Platelets/metabolism, Dietary Supplements, Dose-Response Relationship, Drug, Erythrocyte Membrane/drug effects, Erythrocyte Membrane/metabolism, Fatty Acids/metabolism, Fatty Acids, Omega-3/administration & dosage, Fatty Acids, Omega-3/pharmacokinetics, Female, Healthy Volunteers, Heart Rate/drug effects, Humans, Lactic Acid/blood, Male, Middle Aged, Pilot Projects, Prospective Studies, Triglycerides/blood
Pubmed
Création de la notice
10/12/2014 15:19
Dernière modification de la notice
03/03/2018 21:15
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